The lecture goes on, but unfortunately the video doesn’t; this is too bad, because then Vonnegut describes Kafka’s The Metamorphosis:
Poor old Gregor Samsa. Not only does he start really low on the GI-axis (good fortune, ill fortune), he turns into a cockroach and experiences infinite ill-fortune.
The full text of Vonnegut’s lecture can be found at Lapham’s Quarterly, where he goes on to explain why Hamlet is still regarded as one of the world’s great bits of literature.